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SFRP1
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Breast myoepithelial cells, Breast glandular cells, Leydig cells, Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (hTERT-RPE1)
Interaction
Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4, WNT8 and MYOC (By similarity).
Molecular function
Developmental protein
More Types Infomation
- Rabbit Anti-SFRP1 Polyclonal Antibody (MRO-2183-CN) (MRO-2183-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ICC, IHC, IP
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.