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SIGLEC5

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
Protein class

CD markers

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Kupffer cells, granulocytes, Hofbauer cells, Macrophages, monocytes)

Immune cell specificity

Group enriched (neutrophil, non-classical monocyte)

Cell line specificity

Group enriched (HMC-1, U-937)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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