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SIM2
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Basal squamous epithelial cells, Squamous epithelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (hTERT-RPE1, PC-3, RPTEC TERT1, RT4)
Interaction
Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM2 and ARNT.
Molecular function
Developmental protein, DNA-binding
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.