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SIX2
This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Skeletal myocytes, Ionocytes, Basal respiratory cells, Cardiomyocytes, Smooth muscle cells, Fibroblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC TERT1, LHCN-M2, RH-30, SCLC-21H, U-2197, U-698)
Interaction
Interacts with TCF7L2; in a canonical Wnt signaling independent manner; prevents transcription of differentiation genes in cap mesenchyme. Interacts with OSR1; form a strong repressor complex with TCF7L2, TLE2 and TLE3 to prevent the activation of Wnt/beta-catenin target genes in the cap mesenchyme. Interacts with HOXA11, EYA1 and EYA3.
Molecular function
Developmental protein, DNA-binding
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.