Disease related genes, Human disease related genes, Transcription factors
Intracellular
Group enriched (Muller glia cells, Bipolar cells, Horizontal cells)
Immune cell enhanced (basophil)
Group enriched (hTERT-RPE1, SCLC-21H, SH-SY5Y)
Interacts with EYA4; translocates EYA4 from the cytoplasm to the nucleus and promotes activation of their target genes (By similarity). Interacts with MTA1 and HDAC2; represses its own transcription (By similarity). Interacts with MTA1; facilitates the binding of SIX3 to the core DNA motif of SIX3 promoter (By similarity). Interacts with EYA1; promotes EYA1 translocation to the nucleus (By similarity). Interacts with TLE1 and TLE5 (via Q domain); can act in combination with either TLE1 and/or TLE5 leading to transcriptional repression or activation, respectively. Interacts (via homeobox) with NR4A3; differentially regulates the transcriptional activities NR4A3. Interacts with GMNN. Interacts with TLE4.
Developmental protein, DNA-binding, Repressor
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For Research Use Only. Not For Clinical Use.