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SLC26A3

The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea.
Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enriched (Distal enterocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (RPMI-8226)

Interaction

Interacts with CFTR, SLC26A6 and SLC9A3R1 (By similarity). Interacts with PDZK1.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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