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SMAD9

The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.
Protein class

Disease related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Glandular and luminal cells, Enteroendocrine cells, Astrocytes, Hepatic stellate cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (fHDF/TERT166, HEK93, SH-SY5Y)

Interaction

Interaction with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit. Interacts with RANBP3L (PubMed:25755279).

Molecular function

DNA-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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