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SOD3

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.
Protein class

Enzymes, Metabolic proteins, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Fibroblasts, Smooth muscle cells, Leydig cells, Peritubular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC diff, BJ, PC-3, RPTEC TERT1)

Interaction

Homotetramer (PubMed:19289127). Directly interacts with ATP7A; this interaction is copper-dependent and is required for SOD3 activity (PubMed:16371425).

Molecular function

Antioxidant, Heparin-binding, Oxidoreductase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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