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ST8SIA4

Polysialic acid (polySia) is a carbohydrate modification of the neural cell adhesion molecule (NCAM), which is implicated in neural differentiation and plays an important role in tumor development and metastasis. Polysialylation of NCAM is mediated by two Golgi-resident polysialyltransferases (polyST) ST8SiaII and ST8SiaIV.
Protein class

Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Langerhans cells, Microglial cells, monocytes, Kupffer cells, Plasma cells, Inhibitory neurons)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Cell line enhanced (AF22, HDLM-2, Karpas-707, NB-4, RPMI-8226)

Molecular function

Glycosyltransferase, Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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