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STRA6

The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene.
Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Endometrial stromal cells, Syncytiotrophoblasts, Club cells, Fibroblasts, Extravillous trophoblasts, Proximal tubular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (A549, CAPAN-2, SH-SY5Y, WM-115)

Interaction

Homodimer (By similarity). Interacts with JAK2 and STAT5 (PubMed:21368206). Interacts (via extracellular domains) with RBP4 (PubMed:22665496). Interacts (via cytoplasmic domains) with RBP1 (PubMed:22665496).

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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