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STX1A
Enables several functions, including ATP-dependent protein binding activity; calcium-dependent protein binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; positive regulation of secretion by cell; and synaptic vesicle exocytosis. Located in several cellular components, including actomyosin; presynaptic active zone membrane; and secretory vesicle. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in glutamatergic synapse. Is integral component of presynaptic membrane and integral component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A).
Protein class
Human disease related genes, Plasma proteins, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Excitatory neurons, Enteroendocrine cells, Pancreatic endocrine cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (SCLC-21H, U-87 MG)
Interaction
Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex constitutes the basic catalytic machinery of the complex neurotransmitter release apparatus (PubMed:26635000). The SNARE complex interacts with CPLX1 (By similarity). Interacts with STXBP1 (PubMed:12730201, 26635000). Interacts (via C-terminus) with KCNB1 (via C-terminus); the interaction increases in a calcium-dependent manner and induces a pore-independent enhancement of exocytosis in neuroendocrine cells, chromaffin cells, pancreatic beta cells and from the soma of dorsal root ganglia (DRG) neurons (By similarity). Interacts with SYTL4 (By similarity). Interacts with STXBP6 (By similarity). Interacts with PLCL1 (via C2 domain) (By similarity). Interacts with OTOF (By similarity). Interacts with LGI3 (By similarity). Interacts with SLC6A4 (By similarity). Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity). Interacts with VAMP8 (PubMed:12130530). Interacts with SNAP23 (PubMed:12130530). Interacts with VAPA and SYBU (PubMed:15459722). Interacts with PRRT2 (By similarity). Interacts with SEPT8 (By similarity). Interacts with STXBP5L (By similarity). Interacts with synaptotagmin-1/SYT1 (By similarity). Interacts with SEPTIN5; in the cerebellar cortex (By similarity). Interacts with SEPTIN4; in the striatum (By similarity).
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: IHC-P
- Human Anti-STX1A Recombinant Antibody (clone 13C4) (HPAB-0040LY)
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- Derivation: Human
- Species Reactivity: Human
- Type: Humanized IgG1
- Application: WB, Inhib
- Human Anti-STX1A Recombinant Antibody (clone 13C4); Fab Fragment (HPAB-0040LY-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Humanized Fab
- Application: WB
- Human Anti-STX1A Recombinant Antibody (clone 13C4); scfv Fragment (HPAB-0040LY-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Humanized scfv
- Application: WB
- Rabbit Anti-STX1A Recombinant Antibody (VS-0223-WK76) (VS-0223-WK76)
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- Derivation: Rabbit
- Species Reactivity: Human, Rat, Mouse
- Type: Rabbit IgG
- Application: WB, IP, ICC, IHC, IHC-P
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For Research Use Only. Not For Clinical Use.