SULT2B1

Sulfotransferasefamily cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1,Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2,is a cytoplasm protein which belongs to the sulfotransferase 1 family. Thehuman hydroxysteroid sulfotransferase (SULT) family is comprised of twosubfamilies, SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta,prostate and trachea. A lesser expression of SULT1B1 was observed in the smallintestine and lung. SULT2B1 catalyzes the sulfate conjugation of many hormones,neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases thewater solubility of most compounds, and therefore their renal excretion, but itcan also result in bioactivation to form active metabolites. SULT2B1 sulfateshydroxysteroids like DHEA. Isoform 1 preferentially sulfonatescholesterol. The two SULT2B1 isoforms, SULT2B1a and SULT2B1b, are encoded by asingle gene as a result of alternative transcription initiation and alternativesplicing. SULT2B1b catalyzes the sulfonation of 3beta-hydroxysteroid hormonesand cholesterol, whereas SULT2B1a preferentially catalyzes pregnenolonesulfonation.