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TAB3
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6 (PubMed:14633987, PubMed:14670075, PubMed:14766965). The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2 (PubMed:14670075). However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3 (PubMed:14670075). Interacts with DYNC2I2 (via the WD domains) (PubMed:19521662). Interacts with RBCK1 (PubMed:17449468). Binds 'Lys-63'-linked polyubiquitin chains (PubMed:22158122). Interacts with TRIM5 (PubMed:21512573). Interacts with TRIM38 (via B30. 2/SPRY domain), leading to its translocation to lysosomes and degradation (PubMed:24434549). (Microbial infection) Interacts with M. tuberculosis PtpA, which blocks the NF-kappa-B signaling pathway.
More Types Infomation
Related Signaling Pathways
TLR Signaling Pathway
TNF Signaling Pathway
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC
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For Research Use Only. Not For Clinical Use.