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TFPI

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This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.

Derivation:
Humanized
Species Reactivity:
Human
Type:
IgG4 - kappa
Application:
ELISA, IP, FC, FuncS, Neut, IF, WB
Derivation:
Phage display library screening
Species Reactivity:
Human
Type:
IgG
Application:
WB
Species Reactivity:
Human
Type:
Mouse IgG1, κ
Application:
ELISA
Species Reactivity:
Human, Mouse, Rabbit
Type:
Mouse IgG
Application:
ELISA
Derivation:
Chimeric (Mouse/Human)
Species Reactivity:
Human, Mouse, Rabbit
Type:
Chimeric (Mouse/Human) IgG1, κ
Application:
ELISA, Neut
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized IgG1, κ
Application:
ELISA, Neut
Derivation:
A scFv phage display library
Species Reactivity:
Human, Mouse, Rat, Cynomolgus monkey, Rabbit
Type:
Human IgG
Application:
ELISA, Neut
Derivation:
A scFv phage display library
Species Reactivity:
Human, Mouse, Rat, Cynomolgus monkey, Rabbit
Type:
Human IgG
Application:
ELISA, Neut
Species Reactivity:
Human, Mouse, Rabbit
Type:
Mouse IgG1, κ
Application:
ELISA, Neut
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized IgG4, κ
Application:
ELISA, Neut
Derivation:
Chimeric (Mouse/Human)
Species Reactivity:
Human, Mouse, Rabbit
Type:
Chimeric (Mouse/Human) IgG4, κ
Application:
ELISA, Neut
Species Reactivity:
Human, Mouse, Rabbit
Type:
Mouse IgG
Application:
ELISA, FC
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized IgG
Application:
ELISA, FC
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized IgG
Application:
ELISA, FC
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized IgG
Application:
ELISA, FC
Species Reactivity:
Human
Type:
Mouse scFv
Application:
ELISA
Species Reactivity:
Human, Mouse, Rabbit
Type:
Mouse scFv
Application:
ELISA
Species Reactivity:
Human, Mouse, Rabbit
Type:
scFv
Application:
ELISA, Neut
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized scFv
Application:
ELISA, Neut
Derivation:
A scFv phage display library
Species Reactivity:
Human, Mouse, Rat, Cynomolgus monkey, Rabbit
Type:
Human scFv
Application:
ELISA, Neut
Derivation:
A scFv phage display library
Species Reactivity:
Human, Mouse, Rat, Cynomolgus monkey, Rabbit
Type:
Human scFv
Application:
ELISA, Neut
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