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TFPI

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Tissue Factor Pathway Inhibitor is a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia.

Species Reactivity:
Human
Application:
ELISA, WB
Derivation:
Phage display library screening
Species Reactivity:
Human
Type:
IgG
Application:
WB
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized scFv
Application:
ELISA, FC
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized scFv
Application:
ELISA, FC
Species Reactivity:
Human, Mouse, Rabbit
Type:
Mouse Fab
Application:
ELISA
Species Reactivity:
Human, Mouse, Rabbit
Type:
Fab
Application:
ELISA, Neut
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized Fab
Application:
ELISA, Neut
Derivation:
A scFv phage display library
Species Reactivity:
Human, Mouse, Rat, Cynomolgus monkey, Rabbit
Type:
Human Fab
Application:
ELISA, Neut
Derivation:
A scFv phage display library
Species Reactivity:
Human, Mouse, Rat, Cynomolgus monkey, Rabbit
Type:
Human Fab
Application:
ELISA, Neut
Species Reactivity:
Human, Mouse, Rabbit
Type:
Mouse Fab
Application:
ELISA, Neut
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized Fab
Application:
ELISA, Neut
Species Reactivity:
Human, Mouse, Rabbit
Type:
Fab
Application:
ELISA, Neut
Species Reactivity:
Human, Mouse, Rabbit
Type:
Mouse Fab
Application:
ELISA, FC
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized Fab
Application:
ELISA, FC
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized Fab
Application:
ELISA, FC
Derivation:
Humanized
Species Reactivity:
Human, Mouse, Rabbit
Type:
Humanized Fab
Application:
ELISA, FC
Derivation:
Phage display library
Species Reactivity:
Human, Mouse, Rabbit, Rat, Cynomolgus
Type:
Human IgG
Application:
ELISA, FC, FunS
Derivation:
Phage display library
Species Reactivity:
Human, Mouse, Rabbit, Rat, Cynomolgus
Type:
Human IgG
Application:
ELISA, FC, FunS
Derivation:
Chimeric (Human/Mouse)
Species Reactivity:
Human, Mouse, Rabbit, Cynomolgus
Type:
Chimeric (Human/Mouse) IgG1
Application:
ELISA, FC
Derivation:
Phage display library
Species Reactivity:
Human, Mouse, Rabbit, Rat, Cynomolgus
Type:
Human scFv
Application:
ELISA, FC, FunS
Derivation:
Human
Species Reactivity:
Human
Type:
ADCC enhanced antibody
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