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TFPI2
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants.
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts, Ductal cells, Glandular and luminal cells, Prostatic glandular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (EFO-21, hTEC/SVTERT24-B, U-138 MG, U-2197, U-87 MG)
Interaction
Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
Molecular function
Protease inhibitor, Serine protease inhibitor
More Types Infomation
- Mouse Anti-TFPI2 Recombinant Antibody (clone CBL592) (NEUT-1998CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: IP, Neut
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- Species Reactivity: Human
- Application: IHC-P
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, IHC, ELISA
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For Research Use Only. Not For Clinical Use.