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THPO

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.
Protein class

Cancer-related genes, Disease related genes

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Hepatocytes, Proximal tubular cells, Late spermatids, Early spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (CACO-2, Hep G2, K-562, RPMI-8226)

Molecular function

Cytokine, Hormone

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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