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TLR5

Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Kupffer cells, Glandular and luminal cells, Microglial cells, Club cells)

Immune cell specificity

Group enriched (classical monocyte, intermediate monocyte, neutrophil, myeloid DC, non-classical monocyte)

Cell line specificity

Cell line enhanced (A-431, HaCaT, OE19, SK-BR-3, T-47d)

Interaction

Homodimer (PubMed:22173220). Interacts with MYD88 (via TIR domain) (PubMed:20855887). Interacts with TICAM1 (via TIR domain) (PubMed:20855887). Interacts with UNC93B1; this interaction is essential for proper TLR5 localization to the plasma membrane (PubMed:24778236).

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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