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TMEM30A

TMEM30A functions as the beta subunit for several P4 ATPases, playing a role in their catalytic reaction cycles and regulating their correct membrane localization.
Protein class

Transporters

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Component of various P4-ATPase flippase complexes which consists of a catalytic alpha subunit and an accessory beta subunit (PubMed:31416931). Interacts with ATP8A1 to form a flippase complex; this complex forms an intermediate phosphoenzyme (PubMed:31416931). The ATP8A2:TMEM30A flippase complex has been purified, and ATP8B1:TMEM30A and ATP8B2:TMEM30A flippase complexes have been shown to form intermediate phosphoenzymes in vitro. Interacts with alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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