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TNFRSF10C

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
Protein class

Cancer-related genes, CD markers

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Gastric mucus-secreting cells, granulocytes, Alveolar cells type 2, Alveolar cells type 1, Proximal enterocytes, Endothelial cells)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Group enriched (BEWO, HUVEC TERT2)

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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