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TNFRSF14
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants.
Protein class
Cancer-related genes, CD markers, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal enterocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (SK-MEL-30)
Interaction
Interacts with TRAF2, TRAF3 and TRAF5 (PubMed:9153189, PubMed:9162022). Interacts (via CRD1/TNFR-Cys 1) with CD160; this interaction is direct (PubMed:18193050, PubMed:23761635). Interacts with LTA and TNFSF14 (PubMed:9462508). Interacts (via CRD1/TNFR-Cys 1) in cis and trans with BTLA; the cis interactions inhibits the trans interactions (PubMed:19915044, PubMed:16169851). (Microbial infection) Interacts with herpes simplex virus 1/HHV-1 envelope glycoprotein D. (Microbial infection) Interacts with herpes simplex virus 2/HHV-2 envelope glycoprotein D.
Molecular function
Host cell receptor for virus entry, Receptor
More Types Infomation
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- Species Reactivity: Human
- Application: FC, ICC/IF, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, ICC, IF, IP
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- Species Reactivity: Mouse
- Type: Hamster IgG
- Application: FC, FuncS, WB, IF
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For Research Use Only. Not For Clinical Use.