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TNFRSF18

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This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Derivation:
Humanized
Species Reactivity:
Human
Type:
Antibody
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, Neut, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
RIA, ELISA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
IP, IF, Biosensors, FuncS
Derivation:
Humanized
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Species Reactivity:
Human
Application:
ELISA, FC, WB
Species Reactivity:
Human
Type:
Humanized antibody
Application:
ELISA, FC, WB
Species Reactivity:
Human, Cynomolgus monkey
Type:
Human antibody
Application:
ELISA, FC
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, FC
Species Reactivity:
Human, Cynomolgus monkey
Type:
Human antibody
Application:
ELISA, FC
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, FC
Species Reactivity:
Human
Application:
ELISA, FC, WB
Species Reactivity:
Human
Type:
Humanized antibody
Application:
ELISA, FC, WB
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