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TNFSF12

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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, FC, IP, FuncS, IF, Neut, ICC
Derivation:
Rabbit
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, Neut
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, FC, Neut
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, FC, Neut
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, FC, Neut
Species Reactivity:
Human
Type:
Humanized antibody
Application:
ELISA, FC, Neut
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, FC, Neut
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, FC, Neut
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, FC, Neut
Species Reactivity:
Human
Type:
Humanized antibody
Application:
ELISA, FC, Neut
Species Reactivity:
Human
Application:
WB
Derivation:
Rabbit
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, FuncS
Derivation:
Phage display library screening
Species Reactivity:
Mouse, Rat, Human
Type:
IgG
Application:
WB
Derivation:
Chimeric
Species Reactivity:
Human, Mouse
Application:
E
Derivation:
Chimeric
Species Reactivity:
Human, Mouse
Application:
E
Derivation:
Chimeric
Species Reactivity:
Human, Mouse
Application:
E
Derivation:
Chimeric
Species Reactivity:
Human, Mouse
Application:
E
Derivation:
Chimeric
Species Reactivity:
Human, Mouse
Application:
E
Derivation:
Chimeric
Species Reactivity:
Human, Mouse
Application:
E
Derivation:
Chimeric
Species Reactivity:
Human, Mouse
Application:
E
Derivation:
Chimeric
Species Reactivity:
Human, Mouse
Application:
E
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