Human disease related genes
Intracellular
Cell type enhanced (Pancreatic endocrine cells, Proximal enterocytes)
Low immune cell specificity
Cell line enhanced (HBEC3-KT)
Interacts with TNFAIP3 and IKBKG (polyubiquitinated); facilitates TNFAIP3-mediated de-ubiquitination of NEMO/IKBKG. Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is indicative for participation in an activated TLR-signaling complex. Interacts with HIV-1 matrix protein. Interacts with Shigella flexneri ipah9. 8; the interaction promotes polyubiquitination of IKBKG.
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For Research Use Only. Not For Clinical Use.