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TP73
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Protein class
Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Respiratory ciliated cells, Endometrial ciliated cells, Early spermatids, Basal squamous epithelial cells, Late spermatids, Basal respiratory cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (MOLT-4, RH-30, SCLC-21H, U-698)
Interaction
Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Isoform Beta interacts with WWOX. Interacts (via SAM domain) with FBXO45 (via B30. 2/SPRY domain). Interacts with YAP1 (phosphorylated form). Interacts with HCK (via SH3 domain); this inhibits TP73 activity and degradation. Interacts (via SAM domain) with NQO1; this interaction is NADH-dependent, stabilizes TP73 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome. (Microbial infection) Interacts with Epstein-Barr virus protein EBNA6; this interaction inhibits TP73-mediated apoptotic pathway.
Molecular function
Activator, DNA-binding
More Types Infomation
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- Species Reactivity: Human
- Application: GSA, ICC/IF, IHC-P, IP, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ICC, IHC, IP
- Rabbit Anti-TP73 Recombinant Antibody (clone CBACN-420) (MRO-1157-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-Fr, WB, IP, ICC, IF, IHC-P
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP, ChIP
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC
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For Research Use Only. Not For Clinical Use.