Cancer-related genes
Intracellular
Group enriched (Langerhans cells, monocytes)
Immune cell enhanced (T-reg)
Group enriched (HDLM-2, WM-115)
Homotrimer (PubMed:15383523, PubMed:20385093). Heterotrimer with TRAF2 (PubMed:8069916, PubMed:19287455, PubMed:20385093). Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2 (PubMed:10037686, PubMed:10809768, PubMed:10903733, PubMed:11035039, PubMed:11313261, PubMed:16323247, PubMed:19287455, PubMed:19698991, PubMed:8069916, PubMed:8627180, PubMed:8710854, PubMed:9418902, PubMed:9607925, PubMed:9642260, PubMed:9705938, PubMed:9718306, PubMed:9774460). Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2 (PubMed:11907583, PubMed:20447407, PubMed:20385093). Interacts with NFATC2IP, TRAFD1 and with HIVEP3 (By similarity). Interacts with MAP3K14. Interacts with GPS2 (By similarity).
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For Research Use Only. Not For Clinical Use.