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TRIM32
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
It self-associates (PubMed:19349376). Interacts with DTNBP1 (PubMed:19349376). Interacts with PIAS4/PIASY upon treatment with UVB and TNF-alpha (By similarity). Interacts with AMBRA1; promoting activation of ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). (Microbial infection) Interacts with S. typhimurium protein SseK3; SseK3 does not glycosylate TRIM32.
Molecular function
Transferase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.