Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets
Intracellular
Cell type enhanced (Early spermatids)
Immune cell enhanced (basophil)
Cell line enhanced (MCF7)
Homooligomer and heterooligomer with TRIM24 and TRIM28 family members. Interacts with SMAD4 in unstimulated cells. Found in a complex with SMAD2 and SMAD3 upon addition of TGF-beta. Interacts with SMAD2 and SMAD3. Interacts with SMAD4 under basal and induced conditions and, upon TGF-beta signaling, with activated SMAD2. Forms a ternary complex with SMAD4 and SMAD2 upon TGF-beta signaling.
DNA-binding, Repressor, Transferase
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For Research Use Only. Not For Clinical Use.