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TRIM34

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (B-cells, Gastric mucus-secreting cells, Squamous epithelial cells, T-cells, Basal squamous epithelial cells, Macrophages)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (BEWO, SK-BR-3)

Interaction

Homotrimer. Interacts (via the B30. 2/SPRY domain) with HIV-1 capsid complexes (PubMed:17156811). Interacts (via B-box and SPRY domain) with TRIM5 (PubMed:21680743, PubMed:17156811).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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