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TRIM69

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Protein class

Enzymes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Early spermatids, Late spermatids)

Immune cell specificity

Immune cell enriched (T-reg)

Cell line specificity

Cell line enhanced (Karpas-707, U-266/70, U-266/84)

Interaction

Interacts with PML.

Molecular function

Transferase

More Types Infomation

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