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TRPC6
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters, Voltage-gated ion channels
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Smooth muscle cells, Excitatory neurons, Microglial cells, Club cells)
Immune cell specificity
Immune cell enriched (eosinophil)
Cell line specificity
Cell line enhanced (A549, ASC diff, BJ hTERT+, HEL, RPTEC TERT1)
Interaction
Homodimer; forms channel complex (PubMed:26892346). Interacts with MX1 and RNF24 (PubMed:15757897, PubMed:17850865).
Molecular function
Calcium channel, Ion channel
More Types Infomation
- Chicken Anti-TRPC6 Polyclonal IgY (BRD-0737MZ)
-
- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.