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TSC22D3
The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Plasma cells, T-cells, B-cells, dendritic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC diff, ASC TERT1, HHSteC, hTCEpi, Karpas-707)
Interaction
Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 (By similarity). Interacts with NFKB1. Isoform 1 interacts with MYOD1 (By similarity). Isoform 1 interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity (By similarity).
More Types Infomation
- PE-A2/Human TSC22D3 (SLLGGDVVSV) MHC Tetramer (MHC-LC1948)
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- Class: Class I
- Antigen: TSC22D3
- Antigen Species: Human
- Peptide: SLLGGDVVSV
- Conjugate: PE
- PE-A*02:01/Human TSC22D3 (SLLGGDVVSV) MHC Tetramer (MHC-LC1928)
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- Class: Class I
- Antigen: TSC22D3
- Antigen Species: Human
- Peptide: SLLGGDVVSV
- Conjugate: PE
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, IF, IHC, WB
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- Species Reactivity: Human
- Application: ICC/IF, IHC-P, WB
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For Research Use Only. Not For Clinical Use.