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TSG101
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry (PubMed:18005716). Interacts with VPS37A, VPS37B and VPS37C (PubMed:15218037, 15509564). Interacts with DMAP1 (PubMed:10888872). Interacts with ubiquitin (PubMed:11595185). Interacts with stathmin, GMCL and AATF (By similarity). Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry (PubMed:21757351). Interacts with HGS; the interaction mediates the association with the ESCRT-0 complex. Interacts with GGA1 and GGA3 (PubMed:15143060, 15039775). Interacts (via UEV domain) with PDCD6IP/AIP1 (PubMed:14505570, 14519844). Interacts with VPS28, SNF8 and VPS36 (PubMed:14505570). Self-associates (PubMed:14505570, 14519844). Interacts with MVB12A; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with LRSAM1. Interacts with CEP55; the interaction is required for cytokinesis but not for viral budding (PubMed:17853893). Interacts with PDCD6 (PubMed:18256029). Interacts with LITAF (PubMed:23166352). Interacts with MGRN1 (PubMed:17229889). Interacts with ARRDC1; recruits TSG101 to the plasma membrane (PubMed:21191027, 22315426). (Microbial infection) Interacts with HIV-1 p6. (Microbial infection) Interacts with human spumavirus Gag. (Microbial infection) Interacts with HTLV-1 Gag. (Microbial infection) Interacts with Ebola virus VP40. (Microbial infection) Interacts with EIAV p9; the interaction has been shown in vitro. (Microbial infection) Interacts with Lassa virus protein Z. (Microbial infection) Interacts with hepatitis E virus protein ORF3.
More Types Infomation
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Species Reactivity: Human
- Application: ICC/IF, IHC-P, WB, sELISA
- Recombinant Human Anti-human TSG101 Antibody Fab Fragment (MHH-1011-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: IF, ELISA, FuncS
- Recombinant Anti-human TSG101 Antibody (MOB-1011)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, FuncS
- Recombinant Anti-human TSG101 Antibody scFv Fragment (MOB-1011-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, Neut, FuncS
- Recombinant Anti-human TSG101 Antibody Fab Fragment (MOB-1011-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: FC, WB, FuncS
- Recombinant Human Anti-human TSG101 Antibody scFv Fragment (MHH-1011-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FC, FuncS
- Recombinant Human Anti-human TSG101 Antibody (MHH-1011)
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: IF, FC, Biosensors, FuncS
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Rabbit Anti-TSG101 Recombinant Antibody (VS3-WK1124) (VS3-WK1124)
-
- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, FC
-
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Mouse Anti-TSG101 Recombinant Antibody (VS3-WK1123) (VS3-WK1123)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, ICC, IF
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IF, FC
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