Enzymes
Intracellular
Cell type enhanced (Inhibitory neurons, Extravillous trophoblasts, Langerhans cells, Syncytiotrophoblasts)
Low immune cell specificity
Cell line enhanced (HEL, HMC-1, hTEC/SVTERT24-B, REH)
Homodimer. Interacts with JAK2 (in vitro) (By similarity). Interacts with CBL (PubMed:15159412). Part of a complex containing CBL and activated EGFR (PubMed:15159412). Interacts with ubiquitin and with mono-ubiquitinated proteins (PubMed:15159412). Interacts with ZAP70 (ubiquitinated form) (PubMed:26903241).
Hydrolase, Protein phosphatase
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For Research Use Only. Not For Clinical Use.