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UBASH3B

This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
Protein class

Enzymes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Inhibitory neurons, Extravillous trophoblasts, Langerhans cells, Syncytiotrophoblasts)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HEL, HMC-1, hTEC/SVTERT24-B, REH)

Interaction

Homodimer. Interacts with JAK2 (in vitro) (By similarity). Interacts with CBL (PubMed:15159412). Part of a complex containing CBL and activated EGFR (PubMed:15159412). Interacts with ubiquitin and with mono-ubiquitinated proteins (PubMed:15159412). Interacts with ZAP70 (ubiquitinated form) (PubMed:26903241).

Molecular function

Hydrolase, Protein phosphatase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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