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ULBP1
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Alveolar cells type 1, Breast myoepithelial cells, Squamous epithelial cells, Respiratory ciliated cells, Alveolar cells type 2)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (fHDF/TERT166, HAP1, HDLM-2, HHSteC, JURKAT)
Interaction
Interacts with KLRK1/NKG2D (PubMed:11777960). Does not bind to beta2-microglobulin (PubMed:12782710). (Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes ULBP1 retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.
More Types Infomation
- Mouse Anti-ULBP1 Recombinant Antibody (clone CBL195) (NEUT-2241CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2
- Application: FC, Neut
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: Neut, FC
- Mouse Anti-ULBP1 Recombinant Antibody (clone CBL342) (NEUT-2242CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: Block, CyTOF, FC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, Neut
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.