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UNC13A
This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Horizontal cells, Excitatory neurons, Inhibitory neurons, Cone photoreceptor cells, Bipolar cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HMC-1, NTERA-2, SCLC-21H, SH-SY5Y)
Interaction
Interacts with the N-termini of STX1A and/or STX1B1 and DOC2A. Interacts with BSN. Interacts with RIMS1 which recruits UNC13A to the active zone. Forms homodimers via its first C2 domain. Also interacts via this domain with the zinc finger domain of RIMS2. Part of a complex consisting of ERC2, RIMS1 and UNC13A. Also part of a complex consisting of UNC13A, RIMS2 and RAB3A (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity).
More Types Infomation
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- Species Reactivity: Mouse, Rat
- Application: WB, ELISA
- Recombinant Human Anti-UNC13A Soluble TCR (AC5) (ZIP-Fos/ZIP-Jun) (VS-0622-YF2597)
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- Epitope: FQLNQSFEI
- MHC: HLA-A2
- Recombinant Human Anti-UNC13A Soluble TCR (AC5) (KIH) (VS-0622-YF8013)
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- Epitope: FQLNQSFEI
- MHC: HLA-A2
- Recombinant Human Anti-UNC13A Soluble TCR (AC5) (C-Cys) (VS-0622-YF5305)
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- Epitope: FQLNQSFEI
- MHC: HLA-A2
- Human Anti-UNC13A Recombinant Soluble TCR (clone AC5) (scTCR-1308YC-S(P))
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- Epitope: FQLNQSFEI
- MHC: HLA-A2
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For Research Use Only. Not For Clinical Use.