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UPP1

The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995).
Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Paneth cells, Extravillous trophoblasts, Distal enterocytes, Macrophages)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enriched (hTERT-HME1)

Interaction

Homodimer.

Molecular function

Glycosyltransferase, Transferase

More Types Infomation

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