Enzymes, Metabolic proteins, Plasma proteins
Intracellular
Low cell type specificity
Immune cell enhanced (neutrophil)
Low cell line specificity
A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo (PubMed:22001210). Identified in a complex with the COP9 signalosome complex (CSN) (PubMed:16005295). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct (PubMed:21947082). Forms a complex with SMURF2 and SMAD7 (PubMed:22344298). Interacts with TGFBR1 (PubMed:22344298). Interacts with SART3; the interaction is direct (PubMed:24526689). May interact with RNF20 and RNF40 (PubMed:24526689). May interact with PRKN (PubMed:24852371). Interacts with INCA1 (PubMed:21750715). (Microbial infection) Interacts with human papillomavirus type 16 protein E6.
Hydrolase, Protease, Thiol protease
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For Research Use Only. Not For Clinical Use.