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VEGFC
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, RAS pathway related proteins, Transporters
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Adipocytes, Microglial cells, Endothelial cells, Leydig cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ, HBF TERT88, hTEC/SVTERT24-B, LHCN-M2)
Interaction
Homodimer; non-covalent and antiparallel (PubMed:20145116). Interacts with FLT4/VEGFR3; the interaction is required for FLT4/VEGFR3 homodimarization and activation (PubMed:23878260).
Molecular function
Developmental protein, Growth factor, Mitogen
More Types Infomation
Related Signaling Pathways
TNF Signaling Pathway
- Anti-Human VEGF-C Antibody (MOB-0226MC)
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- Species Reactivity: Human, Mouse, Rat
- Application: WB, ICC/IF, IHC, IHC-P
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ICC, IF, IHC
- Rabbit Anti-VEGFC Polyclonal Antibody (MRO-2271-CN) (MRO-2271-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-Fr, WB
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, Neut
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, WB, BL
-
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC, WB, BL
- Mouse Anti-VEGFC Recombinant Antibody (clone E6) (VS-0224-XY139)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2a, kappa
- Application: ELISA, WB, FC, IF, IP, IHC
- Human Anti-VEGFC Recombinant Antibody (TAB-311CQ-F(E)); Fab Fragment (TAB-311CQ-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, Neut
- Mouse Anti-VEGFC Recombinant Antibody; Fab Fragment (TAB-310CQ-F(E)) (TAB-310CQ-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, WB, BL
- Human Anti-VEGFC Recombinant Antibody; Fab Fragment (TAB-309CQ-F(E)) (TAB-309CQ-F(E))
-
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC, WB, BL
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB
-
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: Block, ELISA, FuncS
-
- Species Reactivity: Human
- Type: Humanized antibody
- Application: Block, ELISA, FuncS
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Application: WB
-
- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1, κ
- Application: WB
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