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The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.
Protein class

Cancer-related genes

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Group enriched (Inhibitory neurons, Melanocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (SH-SY5Y, TIME)

Molecular function

Hormone

More Types Infomation

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