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WIF1

The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers.
WIF1
Protein class

Cancer-related genes

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Muller glia cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HEK93, LHCN-M2, NTERA-2)

Interaction

Interacts with MYOC.

Molecular function

Developmental protein

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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