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WNT5A
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Endometrial stromal cells, Alveolar cells type 1, Basal squamous epithelial cells, Club cells, Oligodendrocyte precursor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, HeLa, SiHa, U-87 MG)
Interaction
Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Homooligomer; disulfide-linked, leading to inactivation (in vitro). Interacts with PORCN. Interacts with WLS (By similarity). Interacts with glypican GCP3 (PubMed:14610063). Interacts with PKD1 (via extracellular domain) (PubMed:27214281).
Molecular function
Developmental protein
More Types Infomation
Related Signaling Pathways
Canonical Wnt Signaling Pathway
mTOR Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Related Diseases
Endometrial Cancer
Throid Cancer
Cushing Syndrome
- Rabbit Anti-WNT5A Recombinant Antibody (clone JU30-30) (MRO-1600-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IF, IHC
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- Species Reactivity: Human
- Application: ELISA, IHC-P, WB
- Rat Anti-WNT5A Recombinant Antibody (VS-0224-XY141) (VS-0224-XY141)
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- Species Reactivity: Human, Mouse
- Type: Rat IgG2a
- Application: WB, IHC, Neut
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, IF, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF
- Mouse Anti-WNT5A Recombinant Antibody (clone 6F2) (VS3-XY1600)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, ICC
- Mouse Anti-WNT5A Recombinant Antibody (clone 3D10) (VS3-XY1599)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
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For Research Use Only. Not For Clinical Use.