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WRB
The Wrb antigen is a high-frequency human erythrocyte antigen invariably absent from En (a -) erythrocytes, which lack glycophorin A. However, glycophorin A from En (a + ) Wr (a + b -) red cells has an amino acid sequence identical to that of glycophorin A from Wr (b + ) erythrocytes.
Protein class
Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Cardiomyocytes, Cytotrophoblasts, Extravillous trophoblasts, Hofbauer cells, Syncytiotrophoblasts, Adipocytes, Fibroblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40 (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:32910895). Within the complex, GET1 and CAMLG form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (PubMed:32910895). Interacts with CAMLG (via C-terminus) (PubMed:23041287, PubMed:31417168, PubMed:32187542). GET3 shows a higher affinity for CAMLG than for GET1 (PubMed:24392163).
More Types Infomation
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- Species Reactivity: Human
- Application: Agg, FC, ICC/IF
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- Species Reactivity: Human
- Type: Mouse IgG3, κ
- Application: Haemagglutinin
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- Type: Mouse IgG2a, κ
- Application: FuncS
- Chicken Anti-WRB Polyclonal IgY (BRD-0857MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.