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YWHAH
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509). Interacts with MEFV (PubMed:27030597).
More Types Infomation
- Mouse Anti-YWHAH Recombinant Antibody (clone 5F2) (VS3-QX1259)
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB, IHC
- Mouse Anti-YWHAH Recombinant Antibody (clone 5G12) (VS3-QX1258)
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB
- Mouse Anti-YWHAH Recombinant Antibody (clone 8H2) (VS3-QX1257)
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: ELISA
- Mouse Anti-YWHAH Recombinant Antibody; Fab Fragment (TAB-0607CLV-F(E)) (TAB-0607CLV-F(E))
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- Species Reactivity: No species cross-reactivity
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-YWHAH Recombinant Antibody (clone 5B2) (VS3-XY1614)
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- Species Reactivity: Human
- Application: WB, IHC
- Mouse Anti-YWHAH Recombinant Antibody (clone 1G2) (VS3-XY1613)
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- Species Reactivity: Human
- Application: ELISA
- Mouse Anti-YWHAH Recombinant Antibody (TAB-0607CLV) (TAB-0607CLV)
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- Species Reactivity: No species cross-reactivity
- Type: Mouse IgG
- Application: ELISA
- Mouse Anti-YWHAH Recombinant Antibody; scFv Fragment (TAB-0607CLV-S(P)) (TAB-0607CLV-S(P))
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- Species Reactivity: No species cross-reactivity
- Type: Mouse scFv
- Application: ELISA
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For Research Use Only. Not For Clinical Use.