Anti-CD79b (clone hu2F2.D7)-MCvcPAB-MMAE ADC
CAT#: ADC-206CL
This ADC product is composed of an anti-CD79b antibody (clone hu2F2.D7) conjugated via MCvcPAB linker to MMAE(thio hu2F2.D7-HC(A118C)-MCvcPAB-MMAE). It has demonstrated a response in hematopoietic tumors treatment by a MOA (Mechanism of Action) as microtubule inhibitor.








Specifications
- Antibody Overview
- hu2F2.D7-HC(A118C) Thio-engineered Antibody
- Clone
- hu2F2.D7
- Antibody Conjugation
- Thio
- Linker
- MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);
- Gene ID
- 974
- UniProt ID
- P40259
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Datasheet
MSDS
COA
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See other products for "Clone hu2F2.D7"
- CAT
- Product Name
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FAMAB-0058-YC-S(P) | Hamster Anti-Cd79b Recombinant Antibody (clone HM79-16); scFv Fragment | FuncS | Hamster scFv |
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HPAB-618-FY-S(P) | Human Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-618-FY-S(P)) | FC, ELISA | Humanized scFv |
HPAB-619-FY-S(P) | Human Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-619-FY-S(P)) | FC, ELISA | Humanized scFv |
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CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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HPAB-N0044-YC-F(E) | Human Anti-CD79b Recombinant Antibody; Fab Fragment (HPAB-N0044-YC-F(E)) | FuncS | Humanized Fab |
HPAB-1059-FY-S(P) | Mouse Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-1059-FY-S(P)) | FC | Mouse scFv |
HPAB-J0055-YC-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-J0055-YC-F(E)) | ELISA, FC, Inhib, FuncS | Humanized Fab |
HPAB-J0056-YC-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-J0056-YC-F(E)) | ELISA, FC, Inhib, FuncS | Humanized Fab |
HPAB-J0057-YC-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-J0057-YC-F(E)) | ELISA, FC, Inhib, FuncS | Humanized Fab |
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VS-0425-YC74 | Recombinant Anti-CD79B Vesicular Antibody, EV Displayed (VS-0425-YC74) | ELISA, FC, Neut, Cell-uptake |
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