Anti-CD79b (clone hu2F2.D7)-MC-MMAF ADC (CAT#: ADC-205CL)

• Antibody Overview
• hu2F2.D7-HC(A118C) Thio-engineered Antibody

• Clone
• hu2F2.D7

• Antibody Conjugation
• Thio

• Linker
• Mc (maleimidocaproyl)

• Linker Class/Description
• Class: Noncleavable linkers
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

• Drug
• MMAF (Monomethyl auristatin F)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);

• Gene ID
• 974

• UniProt ID
• P40259

• ADC-203CL
• Anti-CD79b (clone hu2F2.D7)-SMCC-DM1 ADC

• ADC-204CL
• Anti-CD79b (clone hu2F2.D7)-BMPEO-DMl ADC

• ADC-206CL
• Anti-CD79b (clone hu2F2.D7)-MCvcPAB-MMAE ADC

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