Anti-HER2 (trastuzumab)-hydroxyl amino PEG linker-MMAD (monomethyl auristatin D) ADC (CAT#: ADC-132LCT)

This ADC product is composed of an anti-HER2 antibody (Trastuzumab) conjuagated via a hydroxyl amino PEG linker to MMAD (trastuzumab-hydroxyl amino PEG linker-MMAD). It has demonstrated a response in breast, ovarian and lung cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Humanized (from Mouse) Anti-HER2
  • Clone
  • Trastuzumab
  • Linker
  • hydroxyl amino PEG linker
  • Drug
  • MMAD (monomethyl auristatin D)
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Downloads

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Intrabody

CAT Product Name Application Type
IAB-B008(A) Recombinant Anti-human ERBB2 Intrabody [(D-Arg)9] IF, FC, FuncS scFv-(D-Arg)9
IAB-B008(G) Recombinant Anti-human ERBB2 Intrabody [+36 GFP] WB, ICC, FuncS scFv-(+36GFP)
IAB-B008(T) Recombinant Anti-human ERBB2 Intrabody [Tat] ICC, Neut, FuncS scFv-Tat

Chimeric Antibody

CAT Product Name Application Type
TAB-761 Anti-ERBB2 Recombinant Antibody (Margetuximab) IF, IP, Neut, FuncS, ELISA, FC, WB IgG1 - kappa
TAB-049CT Anti-Human HER2/neu Recombinant Antibody (ChA21) IHC, Inhib, WB, Activ, FC Chimeric antibody (mouse/human)
TAB-049CT-S(P) Anti-Human HER2/neu Recombinant Antibody scFv Fragment (ChA21) WB Chimeric antibody (mouse/human)
TAB-049CT-F(E) Anti-Human HER2/neu Recombinant Antibody Fab Fragment (ChA21) WB Chimeric antibody (mouse/human)

Immunotoxin

CAT Product Name Application Type
AGTO-G022E Anti-ERBB2 immunotoxin 4D5 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G022D Anti-ERBB2 immunotoxin 4D5 (scFv)-DT Cytotoxicity assay, Function study
AGTO-G022G Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel Cytotoxicity assay, Function study
AGTO-G022R Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G022S Anti-ERBB2 immunotoxin 4D5 (scFv)-Sap Cytotoxicity assay, Function study

Fab Glycosylation

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-177LC Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated) ELISA Humanized antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0195MZ Chicken Anti-ERBB2 Polyclonal IgY WB Chicken antibody
BRD-0695MZ Chicken Anti-ERBB2 Polyclonal IgY WB Chicken antibody
BRD-0779MZ Chicken Anti-ErbB2 Polyclonal IgY ICC, IF, IHC, IP Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-737CQ Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4) Block, IP, IF, FC Mouse IgG2a

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-468CQ Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Timigutuzumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-053 Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Pertuzumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-761 Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Margetuximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-005 Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Trastuzumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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