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Tumor Antigens

Representative Tumor Antigens Full List of Tumor Antigens Tested Data-Supported Products for Tumor Antigens

Tumor antigens are unique or overexpressed proteins on the surface of cancer cells, distinguishing them from normal cells and making them prime targets for cancer immunotherapy. These antigens arise due to mutations in cancer cells, abnormal gene expressions, or the presence of viral antigens in virus-induced cancers, playing a pivotal role in the development and progression of tumors. They are classified into several types, including tumor-specific antigens (TSAs), which are unique to cancer cells, and tumor-associated antigens (TAAs), which are present on both cancerous and normal cells but are overexpressed in cancer cells. The discovery and characterization of tumor antigens have revolutionized cancer treatment by enabling the development of targeted therapies, such as cancer vaccines, monoclonal antibodies, and adoptive cell therapies. These treatments aim to stimulate the patient's immune system to recognize and destroy cancer cells specifically, offering a more personalized and less toxic alternative to traditional cancer treatments like chemotherapy and radiation. Furthermore, the identification of tumor antigens has facilitated the development of diagnostic and prognostic biomarkers, providing valuable tools for early cancer detection, monitoring treatment response, and predicting patient outcomes.

Figure 1 Mechanism of action of immune checkpoint inhibitors. (Lopez-Beltran, 2018) Figure 1 Structural and Functional Basis of chimeric antigen receptor (CAR).

Representative Tumor Antigen Molecules

CA9

Carbonic Anhydrase IX (CA9) is a transmembrane enzyme belonging to the carbonic anhydrase family, primarily recognized for its role in regulating cellular pH. CA9 is distinct for its expression primarily in response to hypoxic conditions, a characteristic environment of various solid tumors, making it a marker of tumor hypoxia and an attractive target for cancer therapy. The enzyme catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons, a fundamental process in maintaining acid-base balance and facilitating CO2 transport. In the tumor microenvironment, CA9 expression contributes to the acidification of the extracellular space, enabling tumor cells to survive and proliferate under hypoxic conditions, thus promoting tumor growth and metastasis. Additionally, CA9 plays a crucial role in cell adhesion and migration, indicating its involvement in cancer progression beyond its enzymatic function. The overexpression of CA9 in a wide range of solid tumors, coupled with its limited expression in normal tissues, underscores its potential as a biomarker for cancer diagnosis and prognosis, as well as a therapeutic target.

Recommended Mouse Anti-CA9 mAb (CAT#: PABZ-017)
Figure 2 Anti-CA9 Antibody (PABZ-017) in ELISA.
Figure 2 ELISA analysis of PABZ-017 was performed by coating with Human CA9 Protein (His Tag).
Recommended Human Anti-CA9 mAb (CAT#: TAB-1458CL)
Figure 3 Anti-Human CA9 Recombinant Antibody (TAB-1458CL) in DB
Figure 3 Dot blot analysis of TAB-1458CL was performed by loading Recombinant Human Carbonic Anhydrase IX protein (His tag). TAB-1458CL incubation concentration: 2 ng/μL. The secondary antibody: HRP-Anti-Human IgG (H+L).
Recommended Mouse Anti-CA9 mAb (CAT#: ZG-0057J)
Figure 5 Mouse Anti-CD63 Recombinant Antibody (ZG-0127J) in IHC
Figure 4 Immunofluorescence analysis of human-liver-cancer tissue. 1.CA IX Monoclonal Antibody (red) was diluted at 1:200 (4°C, overnight). 2, Cy3 labled Secondary Antibody was diluted at 1:300 (room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI.Picture C: merge of A+B.

CD63

CD63, a member of the tetraspanin family, is a transmembrane protein that plays critical roles in various cellular processes, including cell adhesion, migration, and the regulation of signal transduction pathways. This protein is ubiquitously expressed in many cell types and is notably involved in the biogenesis and function of multivesicular bodies (MVBs) and exosomes, small vesicles involved in intercellular communication. CD63 is often used as a marker for these vesicles due to its enrichment in their membranes. Through its interactions with other membrane proteins, lipids, and cytosolic factors, CD63 influences various physiological and pathological processes. It has been implicated in the immune response by modulating the activity of immune cells, such as T cells and dendritic cells, thereby affecting antigen presentation and the inflammatory response. Additionally, CD63 plays a significant role in cancer, where its expression levels and distribution have been associated with tumor progression, metastasis, and the modulation of cancer cell signaling pathways.

Recommended Mouse Anti-CD63 mAb (CAT#: ZG-0127J)
Figure 5 Mouse Anti-CD63 Recombinant Antibody (ZG-0127J) in IHC
Figure 5 Immunohistochemical analysis of paraffin-embedded Malignant melanoma. 1. Antibody was diluted at 1:200 (4°C overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval. 3, Secondary Antibody was diluted at 1:200 (room temperature, 30min).
Recommended Rabbit Anti-CD63 mAb (CAT#: ZG-0593J)
Figure 6 Rabbit Anti-CD63 Antibody (ZG-0593J) in IF
Figure 6 Immunofluorescence staining of A549 cells with ZG-0593J at 1:51, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG (H+L).
Recommended Mouse Anti-CD63 mAb (CAT#: ZG-0255U)
 Figure 7 Mouse Anti-CD63 Antibody (ZG-0255U) in IHC
Figure 7 IHC image of ZG-0255U diluted at 1:500 and staining in paraffin-embedded human lung cancer tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at 37°C. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG labeled by HRP and visualized using 0.05% DAB.

CTNNB1

CTNNB1 (catenin beta 1) is a crucial protein encoded by the CTNNB1 gene in humans, playing a pivotal role in the regulation of cell-cell adhesion and gene transcription. It is a central component of the Wnt signaling pathway, a complex network that influences cell fate determination, migration, and organogenesis during embryonic development and contributes to the maintenance of adult tissue homeostasis. CTNNB1 functions by coordinating with cadherins in cell adhesion complexes, thereby stabilizing cell structure and facilitating intercellular communication. In the nucleus, it acts as a transcriptional coactivator for T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) family members, turning on genes essential for cell proliferation and differentiation. The dysregulation of CTNNB1 is linked to a variety of diseases, including cancer, where mutations can lead to its accumulation and the inappropriate activation of target genes, promoting uncontrolled cell growth and resistance to cell death. Additionally, its role in the Wnt pathway makes it a target for therapeutic intervention in conditions such as colorectal cancer, where aberrant Wnt signaling is a hallmark.

Recommended Mouse Anti-CTNNB1 mAb (CAT#: ZG-0052J)
Figure 8 Mouse Anti-CTNNB1 Recombinant Antibody (ZG-0052J) in IHC
Figure 8 Immunohistochemical analysis of paraffin-embedded human Liver. 1, Betacatenin Antibody was diluted at 1:200(4°C overnight). 2, EDTA pH 9.0 was used for antigen retrieval.
Recommended Mouse Anti-CTNNB1 mAb (CAT#: ZG-0073J)
Figure 9 Mouse Anti-CTNNB1 Recombinant Antibody (clone 4F2) in WB
Figure 9 Immunofluorescence analysis of Mouse-spleen tissue. 1.Catenin-β Monoclonal Antibody (red) was diluted at 1:200 (4°C, overnight). 2, Cy3 labled Secondary Antibody was diluted at 1:300 (room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI.Picture C: merge of A+B
Recommended Rabbit Anti-CTNNB1 mAb (CAT#: VS3-FY425)
Figure 10 Recombinant Rabbit Anti-CTNNB1 Antibody (clone R07-9D5) in ICC
Figure 10 Immunocytochemical analysis of β-catenin (green) in 293T using β-catenin.

Full List of Tumor Antigen Molecules

Biomarker Alternative Names Gene ID UniProt ID Roles
ABL1 ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase; V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 1; C-Abl Oncogene 1, Receptor Tyrosine Kinase; Abelson Tyrosine-Protein Kinase 1; Proto-Oncogene C-Abl; EC 2.7.10.2; JTK7; P150; ABL; Abelson Murine Leukemia Viral Oncogene Homolog 1; C-Abl Oncogene 1, Non-Receptor Tyrosine Kinase 25 A0A024R8E2 This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene. Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
AFP Alpha Fetoprotein; Alpha-1-Fetoprotein; Alpha-Fetoglobulin; HPAFP; Alpha-Fetoprotein; AFPD; FETA 174 P02771 This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
BRCA1 IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53 672 P38398 This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
CA9 CAIX; MN 768 Q16790 Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
CCNB1 Cyclin B1; CCNB; G2/Mitotic-Specific Cyclin B1; G2/Mitotic-Specific Cyclin-B1; 891 P14635 CCNB1 (Cyclin B1) is a Protein Coding gene. Diseases associated with CCNB1 include Thyroid Lymphoma and Adrenal Carcinoma. Among its related pathways are Mitotic Prometaphase and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include protein kinase binding and patched binding. An important paralog of this gene is CCNB2.
CD19 CD19; B4; CVID3; MGC12802 930 P15391 Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
CD22 SIGLEC2; SIGLEC-2 933 P20273 Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome.
CD24 CD24A 100133941 P25063 This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants.
CD5 CD5; LEU1 921 P06127 This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms.
CD63 CD63 antigen; Granulophysin; LAMP-3; Limp1; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30 967 P08962 The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
CDK4 CMM3; PSK-J3 1019 P11802 The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
CEACAM1 CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); BGP; BGP1; BGPI; carcinoembryonic antigen-related cell adhesion molecule 1; antigen CD66; CD66a antigen 634 P13688 This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
CEACAM3 CEA; CGM1; W264; W282; CD66D 1084 P40198 This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described.
CEACAM5 CEACAM-5; CD66e; CEA; Meconium antigen 100 1048 P06731 This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
CEACAM6 CD66c; CEAL; NCA 4680 P40199 This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohns disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19.
CLCA2 CLCA2; Human CLCA2 9635 Q9UQC9
CTAG2 CTAG2; Cancer/testis antigen 2; CT2; ESO2; CAMEL; CT6.2; CT6.2a; CT6.2b; LAGE-1; LAGE2B 30848 O75638 This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants.
CTNNB1 Catenin Beta 1; Catenin (Cadherin-Associated Protein), Beta 1, 88kDa; CTNNB; Catenin (Cadherin-Associated Protein), Beta 1 (88kD); Catenin (Cadherin-Associated Protein), Beta 1; Catenin Beta-1; 12387 Q02248 Catenin beta-1, also known as beta-catenin (β-catenin), is a protein that in humans is encoded by the CTNNB1 gene.
EGFR Epidermal Growth Factor Receptor; Receptor Tyrosine-Protein Kinase ErbB-1; Erb-B2 Receptor Tyrosine Kinase 1; Proto-Oncogene C-ErbB-1; EC 2.7.10.1; ERBB1; ERBB; HER1; Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog); Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian) 1956 P00533 The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
ERBIN Erbb2 Interacting Protein; Densin-180-Like Protein; ERBB2-Interacting Protein; Protein LAP2; ERBB2IP; LAP2 55914 Q96RT1 This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
fibronectin FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2 2335 P02751 Fibronectin (FN) is a glycoprotein component of the extracellular matrix of the extracellular matrix (ECM) with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet thrombus formation and diseases associated with thrombosis including vascular remodeling, atherosclerosis, and cardiac repair following a myocardial infarct. Each monomer of FN consists of three types of homologous repeating units, that is 12 type I repeats, two type II repeats and 15-17 type III repeats. The occurrence of multiple isoforms results from alternative mRNA splicing of the ED-A, ED-B and III-CS regions, and subsequent post-translational modification. As an ECM component and one of the primary cell adhesion molecules, Fibronectin can be a ligand for fibrin, heparin, chondroitin sulfate, collagen/gelatin, as well as many integrin receptors through which FN mediates the variety of cellular signaling pathways. The study of solid human tumors showed among the early signs of malignant transformation the fragmentation of pericellular FN, concommitent with the increase of its production by the peritumoral stroma. These results should encourage further investigations concerning the potential importance of Fn production and breakdown during cancer progression. FN1 expression has been described to increase significantly from the morula towards the early blastocyst stage, suggesting that FN1 may also be involved in early blastocyst formation. The fragment 2 of FN comprises the first 7 FN type III repeats and is suggested to be important for self association during fibril growth via the key module III2.
gp100 YLE-8A; YLEPGPVTL 6490 P40967 This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
HER2 NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu 2064 P04626 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
HMMR Hyaluronan Mediated Motility Receptor; Intracellular Hyaluronic Acid-Binding Protein; Receptor For Hyaluronan-Mediated Motility; IHABP; RHAMM; Hyaluronan-Mediated Motility Receptor (RHAMM); Hyaluronan-Mediated Motility Receptor; CD168 Antigen; CD168 3161 O75330 The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
KLK3 Kallikrein Related Peptidase 3; Gamma-Seminoprotein; P-30 Antigen; Kallikrein-3; Semenogelase; Seminin; APS; PSA 354 P07288 Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
KRAS NS; NS3; CFC2; RALD; K-Ras; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; c-Ki-ras2 3845 P01116 This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
MLANA Melan-A; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A; MART-1; MART1; Melanoma Antigen Recognized By T-Cells 1 2315 Q16655 MLANA (Melan-A) is a Protein Coding gene. Diseases associated with MLANA include Melanoma and Microphthalmia. Among its related pathways are NF-kappaB Signaling.
MSLN Mesothelin; Pre-Pro-Megakaryocyte-Potentiating Factor; CAK1 Antigen; MPF; Soluble MPF Mesothelin Related Protein; Megakaryocyte Potentiating Factor; SMRP; BAY 94-9343; unconjugated:BAY 86-1903; MSLN 10232 Q13421 This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
MUC1 ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; PEM; PEMT; PUM 4582 P15941 This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
MUM1 EXPAND1; HSPC211; MUM-1 84939 Q2TAK8 MUM1 (Melanoma Associated Antigen (Mutated) 1) is a Protein Coding gene. Diseases associated with MUM1 include Melanoma. Among its related pathways are DNA Damage. Gene Ontology (GO) annotations related to this gene include nucleosome binding. An important paralog of this gene is MUM1L1.
NY-ESO-1 NY-ESO-1 1485 P78358 The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence.
p53 7157 K7PPA8
PCNA Proliferating Cell Nuclear Antigen; Cyclin; DNA Polymerase Delta Auxiliary Protein; ATLD2 5111 P12004 The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
PRAME MAPE; OIP4; CT130; OIP-4 23532 P78395 This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
PSA Psa 354 P07288
RAGE Receptor for advanced glycation endproducts; RAGE 11596 Q62151 RAGE (receptor for advanced glycation endproducts), also called AGER, is a 35 kilodalton transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al.
SSX2 SSX2; SSX; HD21; CT5.2; CT5.2A; HOM-MEL-40 6757 Q16385 The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X.
Survivin Survivin; baculoviral inhibitor of apoptosis repeat-containing 5; BIRC5 332 O15392 This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
TERT TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1 7015 O14746 Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
TGFBR2 AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TBR-ii; TBRII; TGFbeta-RII; TGFR-2 7048 P37173 The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
TYRP1 TYRP1; TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN 7306 P17643 This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
WDR46 WD Repeat Domain 46; WD Repeat-Containing Protein BING4; C6orf11; BING4; Chromosome 6 Open Reading Frame 11; WD Repeat-Containing Protein 46; FP221; UTP7 9277 O15213 WDR46 (WD Repeat Domain 46) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol.
WT1 Wilms Tumor 1; WT33; Wilms Tumor Protein; NPHS4; WIT-2; WAGR; AWT1; GUD 7490 P19544 This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]

Tested Data-Supported Products Targeting Tumor Antigen Molecules

CAT Product Name Biomarker Assay Image
TAB-020 Anti-Human EGFR Recombinant Antibody (Panitumumab) EGFR WB
TAB-176 Anti-Human CD22 Recombinant Antibody (Epratuzumab) CD22 WB
TAB-183-F(E) Anti-Human CD22 Recombinant Antibody (Moxetumomab Pasudotox) CD22 SDS-PAGE
TAB-198 Humanized Anti-CD22 Recombinant Antibody (clone Inotuzumab) CD22 ELISA
TAB-884 Mouse Anti-CD5 Recombinant Antibody (clone Zolimomab) CD5 SDS-PAGE
TAB-710 Anti-EGFR Recombinant Antibody (Nimotuzumab) EGFR WB
TAB-040 Anti-Human EGFR Recombinant Antibody (Zalutumumab) EGFR ELISA
TAB-119 Anti-Human EGFR Recombinant Antibody (Necitumumab) EGFR ELISA
TAB-201 Anti-Human Mesothelin Recombinant Antibody (Amatuximab) MSLN WB
TAB-753 Anti-EGFR Recombinant Antibody (Imgatuzumab) EGFR SDS-PAGE
TAB-899 Humanized Anti-CD22 Recombinant Antibody (clone Pinatuzumab) CD22 WB
TAB-707 Anti-CAIX/CA9 Recombinant Antibody (Girentuximab) CA9 DB
TAB-003 Anti-Human EGFR Recombinant Antibody (Cetuximab) EGFR ELISA
TAB-H49 Anti-Human EGFR Recombinant Antibody (Modotuximab) EGFR SDS-PAGE
AGTO-G076D Anti-CD19 immunotoxin HD37 (IgG)-DT CD19 SDS-PAGE
TAB-108CL Anti-Human CD19 Recombinant Antibody (MDX-1342) CD19 ELISA
TAB-113CL Anti-Human CD24 Recombinant Antibody CD24 ELISA
PABZ-017 Mouse Anti-CA9 Recombinant Antibody (clone M75) CA9 WB
PABW-088 Mouse Anti-EGFR Recombinant Antibody (clone 7A7) EGFR ELISA
PABL-658 Mouse Anti-MSLN Recombinant Antibody (clone MORAb-009) MSLN SDS-PAGE
TAB-1458CL Anti-Human CA9 Recombinant Antibody (MSC3) CA9 SDS-PAGE
TAB-1715CL Anti-Human CD22 Recombinant Antibody (12C5) CD22 SDS-PAGE
TAB-1716CL Anti-Human CD22 Recombinant Antibody (19A3) CD22 SDS-PAGE
TAB-1717CL Anti-Human CD22 Recombinant Antibody (16F7) CD22 FC
TAB-1718CL Anti-Human CD22 Recombinant Antibody (23C6) CD22 FC
TAB-1719CL Anti-Human CD22 Recombinant Antibody (4G6) CD22 FC
TAB-1720CL Anti-Human CD22 Recombinant Antibody (21F6) CD22 FC
TAB-1721CL Anti-Human CD22 Recombinant Antibody (CD22.1) CD22 FC
TAB-1722CL Anti-Human CD22 Recombinant Antibody (CD22.2) CD22 FC
TAB-1728CL Anti-Human CD22 Recombinant Antibody (RFB4) CD22 FC
TAB-1620CL-S(P) Anti-Human CD19 Recombinant Antibody scFv Fragment (HD37) CD19 SPR
TAB-1611CL-F(E) Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1611CL-F(E)) CD19 SDS-PAGE
TAB-001LC Human Anti-CD22 Recombinant Antibody (TAB-001LC) CD22 SDS-PAGE
TAB-002LC Anti-Human CD22 Recombinant Antibody (VM1000) CD22 SDS-PAGE
TAB-003LC Mouse Anti-Human CD22 Recombinant Antibody CD22 SDS-PAGE
TAB-005LC Mouse Anti-CD22 Recombinant Antibody (TAB-005LC) CD22 ELISA
TAB-006LC Mouse Anti-CD24 Recombinant Antibody (TAB-006LC) CD24 ELISA
TAB-308LC Anti-Human CD5 Recombinant Antibody (5D7) CD5 SDS-PAGE
TAB-309LC Anti-Human CD5 Recombinant Antibody (H3L1) CD5 ELISA
TAB-444LC Anti-Human CEACAM6 Recombinant Antibody (NEO-Human 201) CEACAM6 ELISA
TAB-271MZ Mouse Anti-EGFR Recombinant Antibody (TAB-271MZ) EGFR SDS-PAGE
TAB-014MZ-VHH Anti-Human EGFR Recombinant Antibody (OA-cb6) EGFR SDS-PAGE
TAB-293CT Anti-Human RAGE Recombinant Antibody (XT-M4) AGER WB
TAB-418MZ Mouse Anti-MUC1 Recombinant Antibody (TAB-418MZ) MUC1 DB
TAB-428MZ Mouse Anti-MUC1 Recombinant Antibody (TAB-428MZ) MUC1 DB
TAB-439MZ Anti-Human MUC1 Recombinant Antibody (1B2) MUC1 SDS-PAGE
PABX-052 Recombinant Human Anti-EGFR Antibody (Nimotuzumab) EGFR SDS-PAGE
PABX-052-S (P) Recombinant Human Anti-EGFR Antibody scFv Fragment (Nimotuzumab) EGFR SDS-PAGE
TAB-026ML Anti-Human MUC1 Recombinant Antibody (Gatipotuzumab) MUC1 SDS-PAGE
TAB-431CQ Anti-Human CD19 Recombinant Antibody CD19 ELISA
HPAB-0094-YC Mouse Anti-MUC1 Recombinant Antibody (clone 12D10) MUC1 SDS-PAGE
HPAB-0268-CN Human Anti-CD19 Recombinant Antibody (HPAB-0268-CN) CD19 SDS-PAGE
HPAB-0286-CN Human Anti-CEACAM6 Recombinant Antibody (HPAB-0286-CN) CEACAM6 ELISA
HPAB-0288-CN Mouse Anti-CEACAM6 Recombinant Antibody (HPAB-0288-CN) CEACAM6 ELISA
HPAB-0268-CN-S(P) Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0268-CN-S(P)) CD19 ELISA
HPAB-0360-CN Human Anti-CA9 Recombinant Antibody (HPAB-0360-CN) CA9 WB
HPAB-0198-LSX Mouse Anti-CD22 Recombinant Antibody (HPAB-0198-LSX) CD22 SDS-PAGE
HPAB-0199-LSX Human Anti-CD22 Recombinant Antibody (HPAB-0199-LSX) CD22 ELISA
HPAB-0201-LSX Mouse Anti-CD22 Recombinant Antibody (HPAB-0201-LSX) CD22 SDS-PAGE
HPAB-0206-LSX Human Anti-CD22 Recombinant Antibody (clone MJ-7) CD22 ELISA
FAMAB-0046YC Mouse Anti-CD22 Recombinant Antibody (clone m5/44) CD22 SDS-PAGE
HPAB-0150-FY Human Anti-TGFBR2 Recombinant Antibody (clone LY3022859) TGFBR2 SDS-PAGE
HPAB-N0324-YC Mouse Anti-CD22 Recombinant Antibody (HPAB-N0324-YC) CD22 SDS-PAGE
HPAB-N0325-YC Mouse Anti-CD22 Recombinant Antibody (HPAB-N0325-YC) CD22 SDS-PAGE
HPAB-N0376-YC Mouse Anti-PCNA Recombinant Antibody (HPAB-N0376-YC) PCNA WB
HPAB-0646-CN Human Anti-MSLN Recombinant Antibody (HPAB-0646-CN) MSLN WB
HPAB-0727-CN Mouse Anti-EGFR Recombinant Antibody (clone EGFR) EGFR SDS-PAGE
HPAB-0036LY Recombinant Humanized Anti-CD19 Antibody (Hbu12) CD19 SDS-PAGE
HPAB-0418LY Human Anti-CD19 Recombinant Antibody (HPAB-0418LY) CD19 SDS-PAGE
HPAB-1899LY Mouse Anti-CD22 Recombinant Antibody (HPAB-1899LY) CD22 ELISA
HPAB-1900LY Mouse Anti-CD22 Recombinant Antibody (HPAB-1900LY) CD22 SDS-PAGE
HPAB-1901LY Mouse Anti-CD22 Recombinant Antibody (HPAB-1901LY) CD22 ELISA
HPAB-1902LY Mouse Anti-CD22 Recombinant Antibody (HPAB-1902LY) CD22 ELISA
HPAB-1903LY Mouse Anti-CD22 Recombinant Antibody (HPAB-1903LY) CD22 ELISA
HPAB-0709-FY Mouse Anti-CD22 Recombinant Antibody (clone AB008) CD22 ELISA
HPAB-0886-FY Mouse Anti-MSLN Recombinant Antibody (HPAB-0886-FY) MSLN DB
HPAB-0421-WJ Human Anti-CD19 Recombinant Antibody (HPAB-0421-WJ) CD19 WB
HPAB-3383LY-F(E) Mouse Anti-Psa Recombinant Antibody; Fab Fragment (HPAB-3383LY-F(E)) Psa SDS-PAGE
HPAB-0370-FY Human Anti-CD22 Recombinant Antibody (HPAB-0370-FY) CD22 ELISA
ZG-0010C Mouse Anti-EGFR Recombinant Antibody (clone 1B10) EGFR IF
ZG-0011C Mouse Anti-EGFR Recombinant Antibody (clone M6) EGFR WB
ZG-0015C Mouse Anti-MUC1 Recombinant Antibody (clone ABT-EMA) MUC1 IHC
ZG-0016C Mouse Anti-MUC1 Recombinant Antibody (clone PT0132) MUC1 IHC
MOB-0220F Mouse Anti-PCNA Recombinant Antibody (MOB-0220F) PCNA IHC
MOB-0221F Mouse Anti-PCNA Recombinant Antibody (MOB-0221F) PCNA IHC
MOB-0222F Mouse Anti-KLK3 Recombinant Antibody (MOB-0222F) KLK3 IHC
MOB-0223F Mouse Anti-KLK3 Recombinant Antibody (MOB-0223F) KLK3 IHC
ZG-0265F Mouse Anti-AFP Recombinant Antibody (ZG-0265F) AFP WB
ZG-0356F Mouse Anti-ABL1 Recombinant Antibody (ZG-0356F) ABL1 WB
ZG-0375F Mouse Anti-CD19 Recombinant Antibody (ZG-0375F) CD19 WB
ZG-0391F Mouse Anti-CEACAM5 Recombinant Antibody (ZG-0391F) CEACAM5 WB
ZG-0404F Mouse Anti-Cdk4 Recombinant Antibody (ZG-0404F) Cdk4 WB
ZG-0405F Mouse Anti-CDK4 Recombinant Antibody (ZG-0405F) CDK4 WB
ZG-0445F Mouse Anti-CCNB1 Recombinant Antibody (ZG-0445F) CCNB1 WB
ZG-0176C Mouse Anti-WT1 Recombinant Antibody (clone ABT-WT1) WT1 IHC
ZG-0177C Mouse Anti-WT1 Recombinant Antibody (clone PT0264) WT1 IHC
ZG-0294C Mouse Anti-MUM1 Recombinant Antibody (ZG-0294C) MUM1 WB
ZG-0360C Mouse Anti-PCNA Recombinant Antibody (ZG-0360C) PCNA WB
ZG-0361C Mouse Anti-PCNA Recombinant Antibody (ZG-0361C) PCNA WB
ZG-0018J Mouse Anti-AFP Recombinant Antibody (clone 17C5) AFP IHC
ZG-0052J Mouse Anti-CTNNB1 Recombinant Antibody (ZG-0052J) CTNNB1 IHC
ZG-0053J Mouse Anti-CTNNB1 Recombinant Antibody (ZG-0053J) CTNNB1 IHC
ZG-0057J Mouse Anti-CA9 Recombinant Antibody (clone 12F10) CA9 WB
ZG-0067J Mouse Anti-CEACAM5 Recombinant Antibody (clone 1E2) CEACAM5 IHC
ZG-0068J Mouse Anti-CEACAM5 Recombinant Antibody (ZG-0068J) CEACAM5 IHC
ZG-0073J Mouse Anti-CTNNB1 Recombinant Antibody (clone 4F2) CTNNB1 IF
ZG-0119J Mouse Anti-CD5 Recombinant Antibody (ZG-0119J) CD5 IHC
ZG-0120J Mouse Anti-CD5 Recombinant Antibody (ZG-0120J) CD5 IHC
ZG-0121J Mouse Anti-CD5 Recombinant Antibody (clone 10G8) CD5 IHC
ZG-0127J Mouse Anti-CD63 Recombinant Antibody (ZG-0127J) CD63 IHC
ZG-0128J Mouse Anti-CD63 Recombinant Antibody (ZG-0128J) CD63 IHC
ZG-0205J Mouse Anti-CCNB1 Recombinant Antibody (clone 1A5) CCNB1 IHC
ZG-0206J Mouse Anti-CCNB1 Recombinant Antibody (clone 5C1) CCNB1 IHC
ZG-494C Mouse Anti-MLANA Recombinant Antibody (clone 87.1.1) MLANA WB
ZG-0771F Mouse Anti-AFP Recombinant Antibody (clone C3) AFP WB
ZG-0022U Rabbit Anti-CD22 Recombinant Antibody (clone 3D8) CD22 IHC
ZG-0039U Rabbit Anti-CTNNB1 Recombinant Antibody (clone 5E1) CTNNB1 IHC
ZG-0040U Rabbit Anti-WT1 Recombinant Antibody (clone 5F2) WT1 WB
ZG-0082U Rabbit Anti-CEACAM1 Recombinant Antibody (clone 10H8) CEACAM1 IHC
ZG-0578J Rabbit Anti-CA9 Recombinant Antibody (clone 4F12) CA9 IHC
ZG-0586J Rabbit Anti-CD19 Recombinant Antibody (clone 4C7) CD19 WB
ZG-0593J Rabbit Anti-CD63 Recombinant Antibody (clone 2E5) CD63 IHC
ZG-0612J Rabbit Anti-CDK4 Recombinant Antibody (clone 8F2) CDK4 WB
ZG-0613J Rabbit Anti-CDK4 Recombinant Antibody (clone 8H4) CDK4 WB
ZG-0625J Rabbit Anti-CTNNB1 Recombinant Antibody (clone 4C11) CTNNB1 IF
ZG-0642J Rabbit Anti-EGFR Recombinant Antibody (clone 3H9) EGFR WB
ZG-0643J Rabbit Anti-EGFR Recombinant Antibody (clone 1B8) EGFR WB
ZG-0644J Rabbit Anti-EGFR Recombinant Antibody (clone 9F10) EGFR WB
ZG-0645J Rabbit Anti-EGFR Recombinant Antibody (clone 5D4) EGFR WB
ZG-0787J Rabbit Anti-KLK3 Recombinant Antibody (clone 7D4) KLK3 IHC
ZG-0198U Mouse Anti-AFP Recombinant Antibody (clone 4C2A2) AFP IHC
ZG-0203U Mouse Anti-AFP Recombinant Antibody (clone 4G2D2) AFP IHC
ZG-0240U Mouse Anti-CD19 Recombinant Antibody (clone 8G11B7) CD19 WB
ZG-0241U Mouse Anti-CD19 Recombinant Antibody (clone 4C6G1) CD19 WB
ZG-0255U Mouse Anti-CD63 Recombinant Antibody (clone 1H1E11) CD63 WB
ZG-0256U Mouse Anti-CD63 Recombinant Antibody (clone 10F11E6) CD63 WB
ZG-0314U Rabbit Anti-CD5 Recombinant Antibody (clone A25-G) CD5 IHC-P
ZG-0352U Rabbit Anti-MUC1 Recombinant Antibody (clone G22-L) MUC1 IHC-P
ZG-0354U Rabbit Anti-MLANA Recombinant Antibody (clone A19-P) MLANA IHC-P
ZG-0365U Rabbit Anti-EGFR Recombinant Antibody (clone A20-E) EGFR IHC-P
ZG-0395U Rabbit Anti-KLK3 Recombinant Antibody (clone L15-V) KLK3 IHC-P
ZG-0427U Rabbit Anti-CD5 Recombinant Antibody (clone H22-E), FITC CD5 FC
ZG-0591U Rabbit Anti-TERT Recombinant Antibody (clone 5C11) TERT IHC
VS3-FY213 Recombinant Rabbit Anti-Ccnb1 Antibody (clone R08-9B7) Ccnb1 WB
VS3-FY214 Recombinant Rabbit Anti-CCNB1 Antibody (clone R01-7H7) CCNB1 WB
VS3-FY215 Recombinant Rabbit Anti-CCNB1 Antibody (clone R05-3B3) CCNB1 WB
VS3-FY303 Recombinant Mouse Anti-CD5 Antibody (clone 7H6-10F6-5C10) CD5 IHC
VS3-FY308 Recombinant Rabbit Anti-Cd63 Antibody (clone R06-4G3) Cd63 IHC
VS3-FY309 Recombinant Mouse Anti-CD63 Antibody (clone 8H1-8H6-5G7) CD63 IHC
VS3-FY310 Recombinant Rabbit Anti-CD63 Antibody (clone R08-7C9) CD63 WB
VS3-FY346 Recombinant Rabbit Anti-CDK4 Antibody (clone R04-4I5) CDK4 WB
VS3-FY347 Recombinant Rabbit Anti-CDK4 Antibody (clone R04-8I5) CDK4 WB
VS3-FY348 Recombinant Rabbit Anti-CDK4 Antibody (clone R07-4G7) CDK4 WB
VS3-FY368 Recombinant Mouse Anti-CEACAM5 Antibody (clone 10D8-8G10-2A3) CEACAM5 IHC
VS3-FY424 Recombinant Mouse Anti-CTNNB1 Antibody (clone 9A4-10E6-7G5) CTNNB1 IHC
VS3-FY425 Recombinant Rabbit Anti-CTNNB1 Antibody (clone R07-9D5) CTNNB1 WB
VS3-FY472 Recombinant Rabbit Anti-EGFR Antibody (clone R01-2D3) EGFR WB
VS3-FY473 Recombinant Rabbit Anti-EGFR Antibody (clone R03-5C8) EGFR IHC
VS3-FY475 Recombinant Rabbit Anti-EGFR Antibody (clone R05-2A2) EGFR WB
VS3-FY476 Recombinant Rabbit Anti-EGFR Antibody (clone R08-9H7) EGFR WB
VS3-FY799 Recombinant Mouse Anti-KLK3 Antibody (clone 4B3-10G7-9B8) KLK3 IHC-P
VS3-FY930 Recombinant Mouse Anti-MLANA Antibody (clone 4A9-1E7-10H2) MLANA IHC-P
VS3-FY974 Recombinant Mouse Anti-MUC1 Antibody (clone 6A8-8D6-5A2) MUC1 IHC-P
VS3-FY1447 Recombinant Mouse Anti-TGFBR2 Antibody (clone 2C10-2G4-6C8) TGFBR2 IHC-P
VS3-FY1557 Recombinant Mouse Anti-WT1 Antibody (clone 9D1-8B8-4B8) WT1 IHC-P
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Reference
  1. Lopez-Beltran, Antonio, et al. "The identification of immunological biomarkers in kidney cancers." Frontiers in Oncology 8 (2018): 456.

For research use only. Not intended for any clinical use.

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