10-FnIII scaffold protein anti-Human Myostatin (CAT#: SFN-L016)
The tenth fibronectin type III domain (10Fn3) that bound myostatin was isolated from the library using mRNA display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=0.76 nM) for myostatin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human skeletal muscle
(Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg
(Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg
Figure 2 RNA cell line category: Group enriched (LHCN-M2, RH-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN
Specifications
- Scaffold Name
- 10-FnIII
- Origin
- Fibronectin
- Core Structure
- β-sandwich of 7 β-strands
- Variable Regions
- 2–3 Loops
- Target
- Myostatin
- Species Reactivity
- Human
- Expression Host
- BL21 (DE3) cells
- Affinity Constant
- 0.76 nM
- Applications
- ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
Downloads
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Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0476CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0476CL) | ELISA, WB | Mouse IgG |
| TAB-0477CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0477CL) | ELISA, WB | Mouse IgG |
| TAB-0478CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0478CL) | ELISA, WB | Mouse IgG |
| TAB-0479CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0479CL) | ELISA, WB | Mouse IgG |
| TAB-0480CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0480CL) | ELISA, WB | Mouse IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-452MZ | Human Anti-MSTN Recombinant Antibody (TAB-452MZ) | FuncS, Inhib | Human IgG4, λ |
| TAB-460MZ | Human Anti-MSTN Recombinant Antibody (TAB-460MZ) | ELISA, FuncS | Human IgG |
| TAB-461MZ | Human Anti-MSTN Recombinant Antibody (TAB-461MZ) | ELISA, FuncS, Inhib | Human IgG |
| TAB-460MZ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-460MZ-S(P)) | ELISA | Human scFv |
| TAB-461MZ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-461MZ-S(P)) | ELISA | Human scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-456MZ | Anti-Human MSTN Recombinant Antibody (10B3C) | FuncS, Inhib | Chimeric antibody (mouse/human) |
| TAB-456MZ-S(P) | Anti-Human MSTN Recombinant Antibody scFv Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
| TAB-456MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-451MZ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-451MZ-S(P)) | ELISA | Humanized scFv |
| TAB-457MZ-S(P) | Anti-Human MSTN Recombinant Antibody scFv Fragment (H0L0) | ELISA | Humanized antibody |
| TAB-451MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-451MZ-F(E)) | ELISA | Humanized Fab |
| TAB-457MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (H0L0) | ELISA | Humanized antibody |
| TAB-458MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (H1L2) | ELISA | Humanized antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1039MZ | Recombinant Mouse Anti-Human MSTN Antibody (clone 5C0) | ELISA, IHC-P WB | Mouse antibody |
| HPAB-0276LY | Human Anti-MSTN Recombinant Antibody (HPAB-0276LY) | ELISA, Neut, in vivo effect | Humanized IgG4 |
| HPAB-0277LY | Human Anti-MSTN Recombinant Antibody (HPAB-0277LY) | ELISA | Humanized IgG1 |
| HPAB-0278LY | Human Anti-MSTN Recombinant Antibody (HPAB-0278LY) | ELISA | Humanized IgG1 |
| HPAB-0279LY | Human Anti-MSTN Recombinant Antibody (HPAB-0279LY) | ELISA | Humanized IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0775-CN-F(E) | Mouse Anti-MSTN Recombinant Antibody (clone 10B3); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0776-CN-F(E) | Human Anti-MSTN Recombinant Antibody (clone 10B3C); Fab Fragment | ELISA | Human Fab |
| HPAB-0777-CN-F(E) | Human Anti-MSTN Recombinant Antibody (clone 10B3-H2L2); Fab Fragment | ELISA | Human Fab |
| HPAB-0778-CN-F(E) | Human Anti-MSTN Recombinant Antibody (clone H2L2-C91S); Fab Fragment | ELISA | Human Fab |
| HPAB-0276LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0276LY-F(E)) | ELISA, Neut, in vivo effect | Humanized Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0659-WJ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0659-WJ-S(P)) | WB | Human scFv |
| HPAB-0660-WJ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0660-WJ-S(P)) | WB | Human scFv |
| HPAB-3144LY-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-3144LY-S(P)) | ELISA, FC | Human scFv |
| HPAB-0493-FY-S(P) | Mouse Anti-MSTN Recombinant Antibody (clone BP6b- 6); scFv Fragment | Inhib | Mouse scFv |
| HPAB-0494-FY-S(P) | Mouse Anti-MSTN Recombinant Antibody (clone BPla-1); scFv Fragment | ELISA | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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