Recombinant Mouse Antibody (10D5) is capable of binding to APP. This antibody recognizes Aβ residues 3–7.
Figure 1 Application of anti-amyloid antibody 10D5 clears amyloid-β plaques.
Amyloid-β plaque clearance occurred only in cortical tissue treated with 10D5. Amyloid protein was immunostained with fluorescent 3D6. Untreated area of cortexin animal treated with 10D5. Plaques are clearly visible (arrow). Scale bar, 50μm.
Lombardo, J. A., Stern, E. A., McLellan, M. E., Kajdasz, S. T., Hickey, G. A., Bacskai, B. J., & Hyman, B. T. (2003). Amyloid-β antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. Journal of Neuroscience, 23(34), 10879-10883.
Figure 2 Application of anti-amyloid antibody 10D5 clears amyloid-β plaques.
Comparison of amyloid burden measured with 3D6 antibody under different experimental conditions. The values are the means; error bars indicate SD.
Lombardo, J. A., Stern, E. A., McLellan, M. E., Kajdasz, S. T., Hickey, G. A., Bacskai, B. J., & Hyman, B. T. (2003). Amyloid-β antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. Journal of Neuroscience, 23(34), 10879-10883.
Figure 3 Amyloid-β clearance restores the morphology of neurites.
Untreated area of cortex from 10D5-treated animal, immunostained with Cy-3-SMI-32.
Lombardo, J. A., Stern, E. A., McLellan, M. E., Kajdasz, S. T., Hickey, G. A., Bacskai, B. J., & Hyman, B. T. (2003). Amyloid-β antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. Journal of Neuroscience, 23(34), 10879-10883.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-227 | Anti-Human Abeta Recombinant Antibody (Ponezumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG2 - kappa |
TAB-0828CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0828CLV-F(E)) | ELISA | Humanized Fab |
TAB-0829CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0829CLV-F(E)) | ELISA | Humanized Fab |
TAB-0830CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0830CLV-F(E)) | ELISA | Humanized Fab |
TAB-0831CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0831CLV-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0019CL-VHH | Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) | IHC, WB | Camelid VHH |
TAB-0020CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0020CL-VHH) | ELISA, IHC | Single domain antibody |
TAB-0021CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0021CL-VHH) | ELISA, In vivo, FuncS | Single domain antibody |
TAB-0022CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0022CL-VHH) | ELISA, In vivo, FuncS | Single domain antibody |
TAB-0023CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0023CL-VHH) | ELISA, In vivo, FuncS | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-254CQ | Human Anti-APP Recombinant Antibody (TAB-254CQ) | ELISA | Chimeric (mouse/human) IgG1 |
TAB-254CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-254CQ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-0789CLV | Human Anti-APP Recombinant Antibody (TAB-0789CLV) | IP | Chimeric (mouse/human) IgG |
TAB-0802CLV | Human Anti-APP Recombinant Antibody (TAB-0802CLV) | ELISA | Chimeric (mouse/human) IgG1, κ |
TAB-0802CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0802CLV-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0783CLV | Human Anti-APP Recombinant Antibody (TAB-0783CLV) | ELISA, FuncS | Human IgG |
TAB-0801CLV | Anti-Human APP Recombinant Antibody (3H3) | IHC, FuncS | Fully human antibody |
TAB-0815CLV | Human Anti-APP Recombinant Antibody (TAB-0815CLV) | ELISA | Human IgG |
TAB-0815CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0815CLV-F(E)) | ELISA | Human Fab |
TAB-0815CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0815CLV-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0848CLV | Anti-Human APP Recombinant Antibody (2B12) | WB, ELISA | |
TAB-0849CLV | Mouse Anti-APP Recombinant Antibody (TAB-0849CLV) | ELISA, WB, DB | Mouse IgG1 |
TAB-0850CLV | Mouse Anti-APP Recombinant Antibody (TAB-0850CLV) | ELISA, WB, DB | Mouse IgG3 |
TAB-0851CLV | Mouse Anti-APP Recombinant Antibody (TAB-0851CLV) | WB, ICC, IF, ICC | Mouse IgG1 |
TAB-0808CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0808CLV-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0685MZ | Chicken Anti-APP Polyclonal IgY | IHC | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-014 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204) | WB, ELISA, FuncS | Rabbit IgG |
PABX-014-F (E) | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment | WB, ELISA, FuncS | Rabbit Fab |
MOR-0220 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB) | ELISA, WB | Rabbit IgG |
MOR-4539 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS) | IHC-P, ELISA | Rabbit IgG |
MOR-0082-FY | Rabbit Anti-APP Recombinant Antibody (clone AFY0053) | ICC, IHC-P, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0566CQ | Mouse Anti-APP Recombinant Antibody (clone 6E10) | ELISA | Mouse IgG |
EPAF-0567CQ | Mouse Anti-APP Recombinant Antibody (clone 4G8) | ELISA, IHC | Mouse IgG2b |
EPAF-0568CQ | Human Anti-APP Recombinant Antibody (clone HyL5) | ELISA, Inhib | Human IgM |
EPAF-0569CQ | Mouse Anti-APP Recombinant Antibody (clone AB1-42) | IHC | Mouse IgG |
EPAF-0570CQ | Human Anti-APP Recombinant Antibody (clone L11.3) | IHC, ELISA, Inhib | Human IgM |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-001CN | Human Anti-APP Recombinant Antibody (clone AS) | WB | Human IgG |
NS-007CN | Mouse Anti-APP Recombinant Antibody (NS-007CN) | ELISA, FuncS | Mouse IgG1 |
NS-001CN-F(E) | Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment | WB | Human Fab |
NS-007CN-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E)) | ELISA | Mouse Fab |
NS-001CN-S(P) | Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment | WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABC-527 | Mouse Anti-APP Recombinant Antibody (clone c#17) | ELISA, WB, FuncS | Mouse IgG2b |
MRO-1647-CN | Rabbit Anti-APP Polyclonal Antibody (MRO-1647-CN) | WB, IF, IHC, FC | Rabbit IgG |
HPAB-0008-YJ | Mouse Anti-APP Recombinant Antibody (clone 508F) | ELISA | Mouse IgM |
HPAB-0970-FY | Mouse Anti-APP Recombinant Antibody (HPAB-0970-FY) | ELISA | Mouse IgG |
HPAB-0971-FY | Mouse Anti-APP Recombinant Antibody (HPAB-0971-FY) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-225 | Afuco™ Anti-APP ADCC Recombinant Antibody (Bapineuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-228 | Afuco™ Anti-APP ADCC Recombinant Antibody (Solanezumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-229 | Afuco™ Anti-APP ADCC Recombinant Antibody (Gantenerumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-227 | Afuco™ Anti-APP ADCC Recombinant Antibody (Ponezumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-226 | Afuco™ Anti-APP ADCC Recombinant Antibody (Crenezumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0008-YJ-F(E) | Mouse Anti-APP Recombinant Antibody (clone 508F); Fab Fragment | ELISA | Mouse Fab |
HPAB-0732-FY-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0732-FY-S(P)) | DB, ELISA | Mouse scFv |
HPAB-0733-FY-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0733-FY-S(P)) | DB, ELISA | Mouse scFv |
HPAB-0735-FY-S(P) | Human Anti-APP Recombinant Antibody (clone H2L1); Fab Fragment | ELISA, FC, WB | Humanized Fab |
HPAB-0736-FY-S(P) | Human Anti-APP Recombinant Antibody (clone H51L21); Fab Fragment | ELISA, FC, WB | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0255-YJ-S(P) | Human Anti-APP Recombinant Antibody (clone CBA45YJ); scFv Fragment | ELISA, WB, Inhib, FuncS | Human scFv |
HPAB-0971-FY-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0971-FY-F(E)) | ELISA | Mouse Fab |
HPAB-0973-FY-F(E) | Human Anti-APP Recombinant Antibody (clone E12); scFv Fragment | ELISA | Humanized scFv |
HPAB-S0005-YC-S(P) | Human Anti-APP Recombinant Antibody (clone ch3D6); scFv Fragment | ELISA, FuncS | Human scFv |
HPAB-1828-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone 2324); scFv Fragment | ELISA | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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