anti-CD19 immunotoxin HD37 (scFv)-PE (CAT#: AGTO-L047E)

This immunotoxin was achieved by conjugating/fusing the Anti-CD19 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of Head and neck squamous cell cancer or bladder cancer.

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • HD37
  • Molecule Class
  • scFv-PE
  • Toxin Description
  • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Head and neck squamous cell cancer or bladder cancer

Target

  • Alternative Names
  • CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4; Head and neck squamous cell cancer; bladder cancer; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE35

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone HD37"

See other products for "CD19"

Select a product category from the dropdown menu below to view related products.
Please select product type
Mouse Antibody Products Humanized Antibody Products Immunotoxin Products Human Antibody Products Chimeric Antibody Products Fc Glycosylation Antibody Products Low- or Non-fucosylated Oligosaccharide Antibody Products Chicken IgY Antibody Products Neutralizing Antibody Products Blocking Antibody Products Rabbit Monoclonal Antibody Products Fab Antibody Products IgG Antibody Products ScFv Antibody Products ADCC Enhanced Antibody Products Antibody Magnetic Beads
CAT Product Name Application Type
TAB-174 Mouse Anti-CD19 Recombinant Antibody (clone Taplitumomab) ELISA, IP, FC, FuncS, Neut, IF, ICC Mouse IgG1, κ
TAB-1611CL Mouse Anti-CD19 Recombinant Antibody (TAB-1611CL) Depletion, FuncS Mouse IgG2a, κ
TAB-1622CL Mouse Anti-CD19 Recombinant Antibody (TAB-1622CL) ELISA, FC, Apop, ADCC, FuncS Mouse IgG
TAB-1623CL Mouse Anti-CD19 Recombinant Antibody (TAB-1623CL) ELISA, FC Mouse IgG
TAB-1624CL Anti-Human CD19 Recombinant Antibody (381) FC, Inhib, ELISA

Customer Reviews and Q&As

Submit a review or a question

There are currently no Customer reviews or questions for AGTO-L047E. Click the button above to contact us or submit your feedback about this product.

Popular products with customers


For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

  • 0
  • 0
Cart
    Go to compare

    Go to compare